Role of pre and post incisional biopsy levels of Serum Cytokeratin-19 for detection of the dissemination of oral squamous cell carcinoma.

Objective: To evaluate the diagnostic efficacy of cytokeratin 19 for presence and spread oral squamous cell carcinoma following incisional biopsy. Study Design: Descriptive Cross-sectional. Setting: Isra Dental College Hospital, University Hyderabad. Period: November 2020 to October 2021. Material & Methods: Consenting patients either gender, age 20-70 years, with clinical suspicion OSCC were included in study. Patients a previous history chemotherapy radiotherapy, those having biopsy, recurrence excluded. After detailed examination, blood samples all collected before after biopsy sent laboratory further evaluation CK-19 level. Results: Of total 60 patients, majority (86.6%) male. Over half (53.3%) participants belongs age-group 40-59 years. Before participating negative Cytokeratin RT-PCR assay. While (CK-19) was detected positive 12 (20%) within 15 minutes whereas, remaining 48 (80%) showed negativity Statistically significant difference (p<0.05) observed post +ve –ve patients. Male well differentiated tumors had PCR compared their counterparts (p<0.05). Conclusion: Incisional promotes propagation cancerous cells increases risk developing metastatic lesions. Additionally, is reliable tool detection transcripts blood.